Itchy Skin Diseases

Lichen planus. Polygonal, pruritic, purplish, papules with a plain or raised surface accompanied by severe itching is characteristic of lichen planus. Mostly found on the flexor aspect of forearms and legs, at times lichen planus may become generalized and also involve the genital and oral mucosae. Itching in Psychodermatoses or Psychogenic Skin Diseases Psychocutaneous diseases are sometimes overlooked as an important cause for itchy skin conditions. These skin diseases could be very difficult to treat unless the stress and other psychological disturbances are taken care of properly.
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Autoimmune Skin Disorders

Some but not all people with this condition also experience itching and bleeding gums. Cases of bullous pemphigoid have been reported in all age groups, but the disorder most commonly affects the elderly. Men and women are equally at risk for bullous pemphigoid. It is difficult to pin down the incidence of this disease because symptoms come and go, with many patients seeing the condition completely disappear after six years. One estimate is that roughly 5 or 10 new cases of bullous pemphigoid are seen in a typical large hospital each year. If you have symptoms of any of these autoimmune disorders of the skin, see your doctor.
Please visit http://www.everydayhealth.com/autoimmune-disorders/autoimmune-skin-disorders.aspx for the originating report and accompanying media content

Poisonous gases causing skin diseases in Karak

Talking to Dawn here on Friday, office bearers of the committee of 18 villages in the Nashpa block, including Malik Azizur Rehman Khattak, ZarJan Khan and Sher Bahader said according to international laws plantation should be made in 40 kilometer area to neutralise the dangerous effects of the burning gases. They also demanded that steps should also be taken for protection of the environment and wildlife in the areas. Water ponds should be constructed for wildlife in hilly areas of Nashpa, where oil and gas companies are working, they said. The committee office bearers also complained that the Oil and Gas Development Company Limited was giving nothing to local people in shape of welfare projects in return for extracting oil and gas from their soil. They informed that the exploration work had affected water table as a result local people were facing acute shortage of drinking water. They claimed that the OGDCL had given 50 pressure pumps to people to resolve drinking water problem, but the companys regional coordinator made payment to contractor on already installed pressure pumps of the provincial government. They demanded transfer of the regional coordinator of OGDCL, also asking the company to launch welfare projects in the villages.
Link: Poisonous gases causing skin diseases in Karak

Gene Therapy For Epidermolysis Bullosa Skin Disease Produces Long-term Benefits

To evaluate stem cell-based gene therapy as a potential treatment, De Luca and his colleagues previously launched a phase I/II clinical trial at the University of Modena and recruited an EB patient named Claudio. The researchers took skin stem cells from Claudio’s palm, corrected the genetic defect in these cells, and then transplanted them into Claudio’s upper legs. In the new study, De Luca and his team found that this treatment resulted in long-term restoration of normal skin function. Nearly seven years later, Claudio’s upper legs looked normal and did not show signs of blisters, and there was no evidence of tumor development. Remarkably, a small number of transplanted stem cells was sufficient for long-lasting skin regeneration. Even though Claudio’s skin had undergone about 80 cycles of renewal during this time period, the transplanted stem cells still retained molecular features of palm skin cells and did not adopt features of leg skin cells.
Source: http://www.science20.com/news_articles/gene_therapy_epidermolysis_bullosa_skin_disease_produces_longterm_benefits-126985

Stem cells hold cure for deadly skin diseases

Until today, no treatment was available for people with genetic skin disorder known as epidermolysis bullosa (EB), but gene therapy may have an answer to their problem. Researchers at the University of Modena and Reggio Emilia in Italy, after evaluating a patient suffering from EB who underwent gene therapy treatment, found that skin stem cells transplanted into the patients legs restored normal skin function, without causing any side-effects. These findings pave the way for the future safe use of epidermal stem cells for combined cell and gene therapy of epidermolysis bullosa and other genetic skin diseases, Michele De Luca, senior study author, said. The team extracted a small number of skin stem cells from the patients palm, corrected the genetic defect in these cells and then transplanted these into the upper legs. The patients upper legs looked normal and did not show signs of blisters and there was no evidence of tumour development. This finding suggests that adult stem cells primarily regenerate the tissue in which they normally reside, with little plasticity to regenerate other tissues. This research highlights the need to carefully choose the right type of stem cell for therapeutic tissue regeneration, the study, published in the journal Stem Cell Reports, emphasised.
Visit Stem cells hold cure for deadly skin diseases for the originating write-up and relevant media content

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